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Dapoxetine is Safe and Effective for Premature Ejaculation, Study Says

Sep 08, 2016

Dapoxetine is Safe and Effective for Premature Ejaculation

A drug called dapoxetine is a safe, effective method for treating premature ejaculation (PE), according to a team of Turkish researchers.

However, acupuncture could be a viable treatment, too, they noted.

Their study, published online in April in Urologica Internationalis, compared two dose levels of dapoxetine to acupuncture.

PE is one of the most common sexual problems for men. In general terms, it occurs when a man ejaculates before he and his partner wish it to happen. The International Society for Sexual Medicine (ISSM) defines two types of PE. Men with lifelong PE ejaculate within a minute of vaginal penetration and have done so since their first sexual experience. Those with acquired PE typically ejaculate within three minutes of penetration, but have not had the condition all their lives.

The ISSM definition also notes that men with PE are not able to delay the timing of ejaculation and feel distress over their situation.

There are several approaches for treating PE, including medication, sex therapy, and topical treatments that can be applied directly on the penis.

Acupuncture has been practiced in Chinese medicine for over 2,500 years. It involves restoring the balance of energy in the body through the manipulation of tiny needles placed in the skin in certain strategic areas called acupoints. This approach has not been widely studied for treatment of PE.

To learn more, the researchers worked with 120 men with lifelong PE. On average, the participants were in their thirties and had been married for four to five years.

One of the ways experts assess premature ejaculation is by calculating the intravaginal ejaculatory latency time (IELT). Couples measure IELT themselves, using a stopwatch during intercourse.

For this study, men and their partners measured IELT before the study began and again a month later. At these times, the men also completed questionnaires designed to evaluate their ejaculatory function.

The men were randomly assigned to one of four treatment groups. One group took 60 mg of dapoxetine on demand (one to three hours before having sex); another took 30 mg of the drug. A third group had twice-weekly acupuncture sessions. The fourth received “sham” acupuncture, during which a specialist used needles, but did not penetrate the skin. The treatment period lasted for four weeks.

Men who took 60 mg of dapoxetine saw the biggest improvements, with longer IELTs and improved scores on the PE questionnaire. Men who took 30 mg of the drug had the next-best improvements, followed by the men in the acupuncture group and those in the sham group.

Common side effects with dapoxetine included nausea, dizziness, diarrhea, insomnia, and headache.

However, the men who received acupuncture or sham treatment reported no side effects.

The absence of side effects could make acupuncture a “plausible” PE treatment, even if it wasn’t as effective as dapoxetine. But more research is needed, the authors said.

“To the best of our knowledge, this is the first report to compare acupuncture and dapoxetine in the treatment of PE and we think that our results will bring a new perspective to treatment decisions,” they wrote.

It should be noted that dapoxetine is not available in the United States, nor has it been approved for use in that country.  

Resources

Urologica Internationalis

Sahin S., et al.

“A Prospective Randomized Controlled Study to Compare Acupuncture and Dapoxetine for the Treatment of Premature Ejaculation”

(Full-text. First published online: April 7, 2016)

http://www.karger.com/Article/Abstract/445253