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Provider

Irwin Goldstein, MD, Director

Irwin Goldstein, MD

Location

Department

Sexual Medicine

Is provider a surgeon?

Yes

Research and Publications

  • 1. Goldstein, I., Goldstein, S., Urbanetti, J.A. and Anthonisen, N.R.: Effects of Expiratory Threshold Loading During Steady-State Exercise.  J. Appl. Physiol. 39 (5): 697-701, 1975.
  • 2. Olsson, C.A., deVere White, R., Goldstein, I., Traish, A.M., Muller, R.E., and Wotiz, H.H.: A preliminary report on the measurement of cytosolic and nuclear prostatic tissue steroid receptors.  Prog. Clin. Biol. Res. 33: 209 - 221, 1979.
  • 3. Goldstein, I., Cho., S.I. and Olsson, C.A.: Nephrostomy drainage for renal transplant complications. J. Urol. 126: 159-163, 1981.
  • 4. Siroky, M.B., Goldstein, I. and Krane, R.J.: Functional voiding disorders in adult male. J. Urol. 126: 200-204, 1981.
  • 5. Goldstein, I., Siroky, M.B., Sax, D. and Krane, R.J.: Neuro-urologic abnormalities in multiple sclerosis. J. Urol. 128: 541-545, 1982.
  • 6. Goldstein, I., Siroky, M.B., Nath, R.L., McMillian, T.N., Menzoian, J.O. and Krane, R.J.:  Vasculogenic impotence: Role of the pelvic steal test.  J. Urol. 128: 300-306, 1982.
  • 7. Pavlakis, A.J., Siroky, M.B., Goldstein, I. and Krane, R.J.: Neuro-urologic aspects of parkinson's disease.  J. Urol. 129: 80-83, 1983.
  • 8. Pavlakis, A.J., Siroky, M.B., Goldstein, I. and Krane, R.J.: Neuro-urologic findings in conus medullaris and cauda equina injury.  Arch. Neurol. 40: 570-573, 1983.
  • 9. Goldstein, I. and Krane, R.J.:  Drug-induced sexual dysfunction.  World J. Urol. 1: 239-243, 1983.
  • 10. Wheeler, J.S., Jr., Siroky, M.S., Pavlakis, A.J., Goldstein, I. and Krane, R.J.:  The changing neurologic pattern of multiple sclerosis. J. Urol. 130: 1123-1126, 1983.
  • 11. Goldstein, I. Feldman, M.I., Deckers, P.J., Babayan, R. K. and Krane, R.J.:  Radiation-Associated Impotence.  A clinical study of the mechanism.  J.A.M.A. 251: 903-910, 1984.
  • 12. Goldstein, I. LoGerfo, F., Menzoian, J. and Krane, R.J.: Vaculogenic impotence.  Med. Asp. Hum. Sex. 18: 134-144, 1984.
  • 13. Padma-Nathan, H., Goldstein, I. Azadzoi, K., Blanco, R., Saenz de Tejada, I. and Krane, R.J.:  In Vivo and In Vitro Studies on the Physiology of Penile Erection. Sem. Urol. 4: 209-216, 1986.
  • 14. Padma-Nathan, H., Goldstein, I., and Krane, R.J.: Evaluation of the Impotent Male. Sem. Urol. 4: 225-232, 1986.
  • 15. Padma-Nathan, H., Goldstein, I., and Krane, R.J.:  Treatment of Prolonged or Priapistic Erections Following Intracavernosal Papaverine Therapy.  Sem. Urol. 4: 236-238, 1986.
  • 16. Goldstein, I.:  Arterial Revascularization Procedures, Sem. Urol, 4: 252-258, 1986.
  • 17. Frohrib, D.A., Goldstein, I., Payton, T., Padma-Nathan, H. and Krane, R.J.:  Characterization of penile erectile states using external computer-based monitoring.  J. Biomech. Eng. 109: 110-114, 1987.
  • 18. Goldstein, I.:  Penile revascularization. Urol. Clin. North Am.  14: 805-813, 1987.
  • 19. Saenz de Tejada, I., Blanco, R., Goldstein, I., Azadzoi, K., de Las Morenas, A., Krane, R.J. and Cohen, R.A.:  Cholinergic neurotransmission in human corpus cavernosum.  I. Responses of isolated tissue.  Am. J. Physiol. (Heart Circ. Physiol. 23: H459-H467, 1988.
  • 20. Blanco, R., Saenz de Tejada, I., Goldstein, I., Krane, R.J., Wotiz, H.H. and Cohen, R.A.:  Cholinergic neurotransmission in human corpus cavernosum. II.  Acetylcholine synthesis.  Am. J. Physiol (Heart Circ. Physiol. 23: H468-H472, 1988.
  • 21. Goldstein, I., Payton, T. and Padma-Nathan, H.: Therapeutic roles of intracavernosal papaverine.  Cardiovasc. Intervent. Radiol.  11: 237 - 239, 1988.
  • 22. Goldstein, I.: Overview of types and results of vascular surgical procedures for impotence.  Cardiovasc. Intervent. Radiol. 11: 240 - 244, 1988.
  • 23. Saenz de Tejada and Goldstein, I.: Diabetic penile neuropathy.  Urol. Clin. North Am. 15: 17 - 22, 1988.
  • 24. Saenz de Tejada, I., Goldstein, I. and Krane, R.J.:  Local Control of Penile Erection.  Urol. Clin. North Am.  15: 9-15, 1988.
  • 25. Feldman, M.I., Simanovsky, M., Goldstein, I. and Telepun, G.M.  Impotence associated with intersititial implants for prostate carcinoma: Possible etiology. Endocurietherapy Hyperthermia Oncology, 4: 239-242, 1988.
  • 26. Carson, M.P., Saenz de Tejada, I., Goldstein, I. and Haudenschild, C.C.:  Culture of human corpus cavernosum endothelium.  In Vitro Cell. and Develop. Biol. 25: (3) 248-254, 1989.
  • 27. Saenz de Tejada, I., Kim, N., Lagan, I., Krane, R.J. and Goldstein, I.:  Regulation of adrenergic activity in penile corpus cavernosum.  J. Urol.  l42: 1117-1121, 1989.
  • 28. Saenz de Tejada, I., Goldstein, I., Azadzoi, K., Krane, R.J. and Cohen, R.A.:  Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence.  N. Engl. J. Med.  320: 1025-1030, 1989.
  • 29. Krane, R.J., Goldstein, I. and Saenz de Tejada, I.:  Medical progress: Impotence.  N. Engl. J. Med.  321: 1648-1659, 1989.
  • 30. Witt, M. A., Goldstein, I., Saenz de Tejada, I., Greenfield, A. and Krane, R.J.:  Traumatic Laceration of Intracavernosal Arteries:  The pathophysiology of nonischemic, high flow, arterial priapism. J. Urol. 143: 129-132, 1990.
  • 31. Rosen, M. P., Greenfield, A.J., Walker, T. G., Grant, P., Guben, J.K., Dubrow, J., Bettmann, M.A.and Goldstein, I.:  Arteriogenic impotence:  Findings in 195 impotent men examined with selective internal pudendal angiography.  Radiology  174: 1043-1048, 1990.
  • 32. Walker, T.G., Grant, P.W., Goldstein, I., Krane, R.J. and Greenfield, A.J.:  High-flow priapism:  Treatment with superselective transcatheter embolization.  Radiology  174: 1053-1054, 1990.
  • 33. Gasior, B.L., Levine, F.J., Howannesian, A., Krane, R.J. and Goldstein, I.:  Plaque-associated corporal veno-occlusive dysfunction in idiopathic Peyronie's disease: A pharmacocavernosometric and pharmacocavernosographic study.   World J. Urol.  8: 90-96, 1990.
  • 34. Blanco, R., Saenz de Tejada, I., Goldstein, I., Krane, R.J., Wotiz, H.H. Cohen, R.A.:  Dysfunctional penile cholinergic nerves in diabetic impotent men.  J. Urol.  144: 278-280, 1990.
  • 35. Levine, F.J. and Goldstein, I.: Vascular Reconstructive surgery in the management of erectile dysfunction. Int. J. Impot. Res. 2: 59 - 78. 1990.
  • 36. Traish, A.M., Carson, M.P., Kim, N., Goldstein, I.and Saenz de Tejada, I.: Characterization of muscarinic acetylcholine receptors in human penile corpus cavernosum: Studies on whole tissue and cultured endothelium.  J. Urol. 144: 1036 - 1040, 1990.
  • 37. Levine, F.J., Greenfield, A.J., and Goldstein, I.:  Arteriographically-determined occlusive disease within the hypogastric-cavernous bed in impotent patients following blunt perineal and pelvic trauma.   J. Urol. 144: 1147 - 1153, 1990.
  • 38. Azadzoi, K. M., Payton, T., Krane, R.J., and Goldstein, I.:  Effects of intracavernosal trazodone hydrochloride:  Animal and human studies.  J  Urol. 144: 1277 - 1282, 1990.
  • 39. Saenz de Tejada, I., Ware, J.C., Blanco, R., Pittard, J.T., Nadig, P.W., Azadzoi, K., Krane, R.J. and Goldstein, I.:  Pathophysiology of prolonged penile erection associated with trazodone use.  J. Urol.  145: 60 - 64, 1991.
  • 40. Rosen, M. P., Greenfield, A.J., Walker, T.G., Grant, P., Dubrow, J., Bettmann, M.A., Fried, L.E. and Goldstein, I.:  Cigarette smoking:  An independent risk factor for atheroscleroisis in the hypogastric-cavernous arterial bed of men with arteriogenic impotence.  J. Urol. 145: 759 - 763, 1991.
  • 41. Levine, F.J., Saenz de Tejada, I., Payton, T.R. and Goldstein, I:  Recurrent prolonged erections and priapism as a sequela of priapism: Pathophysiology and management.  J. Urol. 145: 764 - 767, 1991.
  • 42. Saenz de Tejada, I., Moroukian P., Tessier, J., Kim, J.J., Goldstein I. and Frohrib, D.: The Trabecular smooth muscle modulates the capacitor function of the penis. Studies on a rabbit model. Am J. Physiol. 260 (Heart Circ. Physiol. 29): H1590 - H1595, 1991.
  • 43. Saenz de Tejada, I., Carson, M.P., de las Morenas A, Goldstein, I and Traish, I.: Endothelin : Location, synthesis, activity and receptor types in the human penis.  Am J. Physiol. 261 (Heart Circ. Physiol. 30): H1078-H1085, 1991.
  • 44. Kim, N., Azadzoi, K.M., Goldstein, I. and Saenz de Tejada, I.: A nitric oxide-like factor mediates non-adrenergic, non-cholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle.  J. Clin. Invest. 88: 112 - 118, 1991.
  • 45. Seftel, A.D., Saenz de Tejada, I., Szetela, B., Cole, J. and Goldstein, I.: clozapine-associated priapism: A case report. J. Urol. 147: 146 - 148, 1992.
  • 46. Azadzoi, K.M., Kim, N., Brown M.L., Goldstein, I., Cohen, R.A. and Saenz de Tejada, I. Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone.  J. Urol. 147: 220 - 225, 1992.
  • 47. Azadzoi, K.M. and Goldstein, I.: Erectile dysfunction due to atherosclerotic vascular disease: The development of an animal model. J. Urol. 147: 1675 - 1681, 1992.
  • 48. Penson, D.F., Seftel, A.D., Krane, R.J., Frohrib, D. and Goldstein, I.:  The hemodynamic pathophysiology of impotence following blunt trauma to the erect penis. J. Urol. 148: 1171 - 1180, 1992. 
  • 49. Seftel, A.D., Oates, R.D. and Goldstein, I: Use of a polytetrafluoroethylene tube graft as a circumferential neotunica during placement of a penile prosthesis. J. Urol. 148: 1531 - 1533, 1992.
  • 50. Seftel, A.D. and Goldstein, I.: Vascular testing for impotence. J. Nucl. Med. 33: 46 - 48, 1992.
  • 51. Kim, N., Vardi, Y., Padma-Nathan, H., Daley, J., Goldstein, I. and Saenz de Tejada, I.: Oxygen tension regulates the nitric oxide pathway.  J. Clin. Invest. 91: 437 - 442, 1993.
  • 52. Pescatori, E.S. and Goldstein, I.: Intraluminal device pressures in 3-piece inflatable penile prostheses: The "pathophysiology" of mechanical malfunction. J. Urol. 149: 295 - 300, 1993. 
  • 53. Hatzichristou, D.G., Goldstein, I., Kasznica, J. and Quist, W.: The native venous architecture is preserved in an arterialized deep dorsal vein graft for arteriogenic impotence: A case report. J. Urol. 149: 851 - 855, 1993.
  • 54. Pescatori, E.S., Engleman.J.C., Davis, G.and Goldstein, I.: Priapism of the clitoris: A case report following trazodone use. J. Urol. 149: 1557 - 1559, 1993.
  • 55. Goldstein, I., Bertero, E.B., Kaufman, J.M., Witten, F.R., Hubbard, J.G., Fitch, W.P., Geller, R.A.,  McKay, D.L., Krane, R.J., Borges, F.D., Babayan, R.K., Tuttle, J.P., Gruber, M.B,  Harik, V. and Levenson, S.: Early experience with the first pre-connected three-piece inflatable penile prosthesis: The Mentor Alpha-1. J. Urol. 150: 1814 - 1818, 1993.
  • 56. Hatzichristou, D. and Goldstein, I.: Penile microvascular arterial bypass: Indications and surgical considerations. Surg. Annu. 25: 207 - 209, 1993.
  • 57. Feldman, H.A., Goldstein, I. Hatzichristou D.G., Krane R.J. and McKinlay J.B.: Impotence and it's medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J. Urol. 151: 54 - 61, 1994. 
  • 58. Kaufman, J.M., Hatzichristou, D.G., Mulhall, J.P., Fitch, W.P. and Goldstein, I: Impotence and chronic renal failure: A study of the hemodynamic pathophysiology. J. Urol. 151: 612 - 618, 1994.
  • 59. Pescatori, E.S., Hatzichristou, D.G. Namburi, S. and Goldstein, I.: A positive intracavernosal injection test implies normal veno-occlusive but not necessarily normal arterial function: A hemodynamic study.  J. Urol. 151: 1209 - 1216, 1994.
  • 60. Hatzichristou, D.G., Goldstein, I. and Quist W.C.: Pre-existing vascular pathology in donor and recipient vessels during penile microvascular arterial bypass surgery.  J. Urol. 151: 1217 - 1224, 1994.
  • 61. Bastuba, M.D.Saenz de Tejada, I., Dinlenc, C.Z., Sarazen, A., Krane, R.J.and Goldstein, I.: Arterial priapism: Diagnosis, treatment and long-term follow up. J. Urol. 151: 1231 - 1237, 1994.
  • 62. Goldstein, I.: Impotence. J. Urol. 151: 1533 - 1534, 1994.
  • 63. Feldman, H.A., Goldstein, I., Hatzichristou, D.G., Krane, R.J.and McKinlay, J.: Construction of a surrogate variable for impotence in the Massachusetts Male Aging Study.  J. Clin. Epidemiol. 47: 457- 467, 1994.
  • 64. Herbener, T.E., Seftel, A.D., Nehra, A. and Goldstein, I.: Penile ultrasound.  Semin. Urol. 12: 320 - 332, 1994.
  • 65. Goldstein, I.: Impotence. J. Urol.  152: 1119 - 1120, 1994.
  • 66. Traish, A.M., Netsuwan, N., Daley, J., Padma-Nathan, H., Goldstein, I. and Saenz de Tejada, I.: A heterogenous population of alpha-1 adrenergic receptors mediates contraction of human corpus cavernosum smooth muscle to norepinephrine. J. Urol. 153: 222 - 227, 1995. 
  • 67. Hall, S. J., Basile, G., Bertero, E. B., de las Morenas, A. and Goldstein, I.: Extensive corporeal fibrosis after penile irradiation. J. Urol. 153: 372 - 377, 1995.
  • 68. Moreland, R.B., Traish, A.M., McMillin, M.A., Smith, B., Goldstein, I. and Saenz de Tejada, I.: PGE1 suppresses the induction of collagen synthesis by transforming growth factor-b1 in human corpus cavernosum smooth muscle.  J. Urol. 153: 826 - 834, 1995.
  • 69. Hatzichristou, D.G., Saenz de Tejada, I., Kupferman, S., Namburi, S., Pescatori, E.S., Udelson, D., and Goldstein I.: In vivo assessment of trabecular smooth muscle tone, It's application in pharmaco-cavernosometry and analysis of intracavernous pressure determinants. J. Urol. 153: 1126 - 1135, 1995.
  • 70. Nehra, A., Hall, S.J., Basile, G., Bertero, E.B., Moreland, R., Toselli, P., de las Morenas, A. and Goldstein, I.: Systemic sclerosis and impotence: A clinicopathological correlation. J. Urol. 153: 1140 - 1146, 1995.
  • 71. Munarriz, R.M., Yan, R.Q., Nehra, A., Udelson D. and Goldstein, I.: Blunt Trauma: The pathophysiology of hemodynamic injury leading to erectile dysfunction. J. Urol. 153: 1831 - 1840, 1995.
  • 72. Gupta, S., Moreland, R.B., Munarriz, R.M., Daley, J., Goldstein, I. and Saenz de Tejada, I.: Possible role of Na+ -K+ -ATPase in the regulation of human corpus cavernosum smooth muscle contractility by nitric oxide. Brit. J. Pharmacol. 116: 2201 - 2206, 1995.
  • 73. Traish, A.M., Gupta, S., Toselli, P., Saenz de Tejada, I., Goldstein, I. and Moreland, R.B.: Identification of alpha-1 adrenergic receptor subtypes in human corpus cavernosum tissue and in cultured trabecular smooth muscle cells. Receptor 5: 145 - 157, 1995.
  • 74. Traish, A.M., Palmer, M.S., Goldstein, I. and Moreland, R.B.: Expression of functional muscarinic acetylcholine receptor subtypes in human corpus cavernosum and in cultured smooth muscle cells. Receptor 5: 159 - 176, 1995.
  • 75. Hakim, L.S., Nehra, A., Kulaksizoglu, H. and Goldstein, I: Penile microvascular arterial bypass surgery.  Microsurgery 16: 296 - 308, 1995.
  • 76. Hakim, L.S., Munarriz, R. M., Kulaksizoglu, H., Nehra, A., Udelson, D. and Goldstein, I.: Vacuum erection associated impotence and peyronie's disease.  J. Urol. 155: 534 - 535, 1996.
  • 77. Hakim, L.S., Kulaksizoglu, H., Mulligan, R., Greenfield, A.and Goldstein, I: Evolving concepts in the diagnosis and treatment of arterial high flow priapism. J. Urol. 155: 541 - 548, 1996.
  • 78. Hakim, L.S., Kulaksizoglu, H., Hamill, B. K., Udelson, D. and Goldstein, I.: A guide to safe corporotomy incisions in the presence of underlying inflatable penile cylinders.  J. Urol. 155: 918 - 923, 1996.
  • 79. Linet, O.L., Ogrinc, F.G. and The Alprostadil Study Group.: Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. New.Engl .J.Med. 334: 873 - 877, 1996.
  • 80. Azadzoi, K.M., Siroky, M.B. and Goldstein, I.: Study of etiologic relationship of arterial atherosclerosis to corporal veno-occlusive dysfunction in the rabbit. J. Urol. 155: 1795 - 1800, 1996.
  • 81. Nehra, A., Goldstein, I., Pabby, A., Nugent, M., Huang, Y-H., de las Morenas, A., Krane , R.J., Udelson, D.G., Saenz de Tejada, I. and Moreland, R.B.: Mechanisms of venous leak: A prospective clinicopathological correlation of corporal function and structure. J. Urol. 156: 1320 - 1329, 1996.
  • 82. Sandock, D.S., Seftel, A.D., Herbener, T.E., Goldstein, I., Greenfield, A.J.:  Perineal abscess after embolization for high-flow priapism.  Urology 48: 308 - 311, 1996.
  • 83. Hakim, L.S., Goldstein, I.:  Diabetic sexual dysfunction.  Endocrinol. Metab. Clin. North Am.  25: 379 - 400, 1996. 
  • 84. Goldstein, I., Newman, L., Baum, N., Brooks, M., Chaikin, L., Goldberg, K., McBride, A. and Krane, R.J.: Safety and efficacy outcome of Mentor Alpha-1 inflatable penile prosthesis implantation for impotence treatment.  J. Urol. 157: 833 - 839, 1997.
  • 85. Azadzoi, K.M., Park, K, Goldstein, I.and Siroky, M.B.: Relationship between cavernosal ischemia and corporal veno-occlusive dysfunction in an animal model. J. Urol. 157: 1011 - 1017, 1997.
  • 86. Park, K., Goldstein, I., Andry, C., Siroky, M.B., Krane, R.J. and Azadzoi, K.M.: Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency.  Int. J. Impot. Res. 9, 27 - 37, 1997.
  • 87. Mulhall, J.P., Daller, M., Traish, A.M., Gupta, S., Park, K., Salimpour, P., Payton, T.R., Krane, R.J. and Goldstein, I.: Intracavernosal forskolin: Role in the management of vasculogenic impotence resistant to standard three-agent pharmacotherapy. J. Urol.  158: 1752 - 1759, 1997.
  • 88. Traish, A.M., Moreland, R.B., Huang, Y-H. and Goldstein, I.: Expression of functional alpha-2 adrenergic receptor subtypes in human corpus cavernosum and in human corpus cavernosum smooth muscle cells. Recept. Signal Transduct. 7: 55 - 67, 1997.
  • 89. Traish, A.M., Moreland, R.B., Gallant, C., Huang, Y-H. and Goldstein, I.: G-protein coupled receptor agonists augment adenylyl cyclase activities induced by forskolin in human corpus cavernosum smooth muscle cells. Recept. Signal Transduct. 7: 123 - 132, 1997.
  • 90. Garcia-Reboll, L., Mulhall, J.P., Goldstein, I.:  Drugs for the treatment of impotence.  Drugs Aging 11:140 - 151, 1997.
  • 91. Koeneman, K.S., Mulhall, J.P. and Goldstein, I.: Sexual healkth for the man at midlife: In-office workup. Geriatrics 52: 76- 78, 1997.
  • 92. Udelson, D., Nehra, A., Hatzichristou, D.G., Azadzoi, K, Krane, R.J., Saenz de Tejada, I. and Goldstein, I.: Engineering analysis of penile hemodynamic and structural-dynamic relationships: Part I - Clinical implications of penile tissue mechanical properties. Int. J. Impot. Res. 10: 15 - 24, 1998.
  • 93. Udelson, D., Nehra, A., Hatzichristou, D.G., Azadzoi, K, Krane, R.J., Saenz de Tejada, I. and Goldstein, I.: Engineering analysis of penile hemodynamic and structural-dynamic relationships: Part II - Clinical implications of penile buckling. Int. J. Impot. Res. 10: 25 - 35, 1998. 
  • 94. Goldstein, I. and Udelson, D.: Axial penile rigidity: Determinants and relation to hemodynamic parameters.  Int. J. Impot. Res. 10 (2): S 28 - S33, 1998.
  • 95. Goldstein, I. and Berman, J.R.: Vasculogenic Female Sexual Dysfunction: Vaginal engorgement and clitoral erectile insufficiency syndrome.  Int. J. Impot. Res. 10 (2): S 84 - S90, 1998.
  • 96. Hussain, S., Nehra, A., Goldstein, I. and Krane, R.J.: Percutaneous core biopsy of the penis. Int. J. Impot. Res. 10: 57 - 60, 1998. 
  • 97. Gupta, S., Salimpour, P., Saenz de Tejada, I., Daley, J., Gholami, S., Daller, M., Krane, R.J., Traish, A.M. and Goldstein , I.: A possible mechanism for alteration of human erectile function by digoxin:  Inhibition of corpus cavernosum Na-K-ATPase Activity.  J. Urol. 159: 1529 - 1536, 1998.
  • 98. Moreland, R.B., Watkins M.T., Nehra, A., Huang, Y-H., Munnariz, R., Salimpour, P., Goldstein, I. and Traish, A.: Oxygen tension modulates TGF-B1-expression and PGE production in human corpus cavernosum smooth muscle cells. Mol. Urol. 2: 41 - 47, 1998.
  • 99. Moreland R.B., Goldstein, I. and Traish, A.M.: Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells. Life Sci. 62 (20): PL 309 - 318, 1998.
  • 100. Gupta, S., Moreland, R.B., Daley, J.T., Yang, S., Goldstein, I and Traish, A.M.: The expression of functional post-synaptic alpha2-adrenoceptors in the corpus cavernosum smooth muscle.  Br. J. Pharmacol. 123: 1237 - 1245, 1998.
  • 101. Goldstein, I., Lue, T., Padma-Nathan, H., Rosen, R., Steers, W. and Wicker, P.: Oral sildenafil in the treatment of erectile dysfunction. New Engl. J. Med.  338:1397-1404, 1998.
  • 102. Araujo, A.B., Durante, R., Feldman, H.A., Goldstein, I. and McKinlay, J.B.: The relationship between depressive symptoms and male erectile dysfunction: Cross-sectional results from the Massachusetts Male Aging Study.  Psychosom. Med., 60: 458 - 465, 1998. 
  • 103. Udelson, D., Nehra, A., Hatzichristou, D.G., Azadzoi, K, Krane, R.J., Saenz de Tejada, I. and Goldstein, I.: Engineering analysis of penile hemodynamic and structural-dynamic relationships: Part III Clinical implications of penile hemodynamic and rigidity erectile responses. Int. J. Impot. Res. 10: 89 - 99, 1998.
  • 104. Nehra, A., Azadzoi, K, Pabby, A., Moreland, R.B., Siroky, M.B., Krane, R.J., Goldstein, I. and Udelson, D.: Cavernosal expandability is an erectile tissue mechanical property which predicts trabecular histology in an animal model of vasculogenic erectile dysfunction. J. Urol. 159: 2229 - 2236, 1998.
  • 105. Park, K., Moreland, R.B., Goldstein, I., Atala, A and Traish, A.: Sildenafil inhibits phosphodiesterase type 5 in human clitoral corpus cavernosum smooth muscle.  Biochem. Biophys. Res. Commun. 249 (3): 612 - 617, 1998.
  • 106. Moreland, R.B., Gupta, S., Goldstein, I. and Traish, A.: Cyclic AMP modulates TGF-B1-induced fibrillar collagen synthesis in cultured human corpus cavernosum smooth muscle cells. Int. J. Impot. Res. 10: 159 - 163, 1998.
  • 107. Sadeghi-Nejad, H., Moreland, R.B., Traish, A.M., Nehra, A., Azadzoi, K.M. and Goldstein, I.: Preliminary report on the development and characterization of rabbit clitoral smooth muscle cell culture.  Int. J. Impot. Res. 10: 165 - 169, 1998.
  • 108. Tarcan, T., Azadzoi, K.M., Siroky, M.B., Goldstein, I. and Krane, R.J.:  Age-related erectile and voiding dysfunction: the role of arterial insufficiency.  Br. J. Urol. 82: Suppl 1: 26-33, 1998. 
  • 109. Traish, A., Gupta, S., Gallant, C., Huang, Y.H., Goldstein, I.:  Phentolamine mesylate relaxes penile corpus cavernosum tissue by adrenergic and non-adrenergic mechanisms.  Int. J. Impot. Res. 10: 215 - 223, 1998. 
  • 110. Azadzoi, K.M., Goldstein, I., Siroky, M.B., Traish, A.M., Krane, R.J., Saenz de Tejada, I.:  Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction.  J. Urol. 160: 2216 - 2222, 1998. 
  • 111. Fitzpatrick, J.M., 
  • 112. , R.S., Krane, R.J., Adolfsson, J., Newling, D.W., Goldstein, I.: Sexual dysfunction associated with the management of prostate cancer.  Eur. Urol. 33: 513 - 522, 1998.
  • 113. Tarcan, T., Park, K., Goldstein, I., Maio, G., Fassina, A., Krane, R.J., Azadzoi, K.M.: Histomorphometric analysis of age-related structural changes in human clitoral cavernosal tissue.  J. Urol. 161: 940-944, 1999
  • 114. Ahn, T.Y., Gomez-Coronado, D., Martinez, V., Cuevas, P., Goldstein, I. and Saenz de Tejada, I.: Enhanced contractility of rabbit corpus cavernosum smooth muscle by oxidized low density lipoproteins.  Int. J. Impot. Res. 11: 9 - 14, 1999
  • 115. Moreland, R.B., Kim, N.N., Goldstein, I. and Traish, A.M.: Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: Research and clinical implications in erectile dysfunction.  Trends Endocrinol. Metab. 10: 97 - 104, 1999.
  • 116. Traish, A.M., Park, K., Dhir, V., Kim, N.N., Moreland, R.B. and Goldstein, I.: Effects of castration and androgen replacement on erectile function in a rabbit model.  Endocrinology, 140: 1861 - 1868, 1999.
  • 117. Azadzoi, K.M., Krane, R.J., Saenz de Tejada, I., Goldstein, I. and Siroky, M.B.: Relative roles of cyclooxygenase and nitric oxide synthase pathways in ischemic-induced increased contraction of cavernosal smooth muscle.  J. Urol. 161: 1324 - 1328, 1999.
  • 118. Nehra, A., Gettman, M.T., Nugent, M.,Bostwick, D.G., Barrett, D.M., Goldstein, I., Krane, R.J. and Moreland, R.B.: Trnasforming growth factor beta (TGF beta-1) is sufficient to induce fibrosis of rabbit corpus cavernosum in vivo. J. Urol 162: 910 - 915, 1999.
  • 119. Berman, J.R., Berman, L. and Goldstein, I.: Female sexual dysfunction: Incidence, pathophysiology, evaluation and treatment options. Urology 54: 385 - 391, 1999.
  • 120. Berman, J.R. and Goldstein, I. Sildenafil in postmenopausal woman with sexual dysfunction.  Urology 54: 578 - 579, 1999.
  • 121. Mulhall, J.P., Jahoda, A.E., Cairney, M., Goldstein, B., Leitzes, R., Woods, J., Payton, T., Krane R.J. and Goldstein, I.: The causes of patient dropout from penile self-injection therapy for impotence. J. Urol. 162: 1291 - 1294, 1999.
  • 122. Nehra, A. and Goldstein, I.: Sildenafil citrate (Viagra) after radical prostatectomy: con.  Urology 54: 587 - 589, 1999.
  • 123. Traish, A., Moreland, R.B., Huang, Y.H., Kim, N.N., Berman, J. and Goldstein, I.: Development of human and rabbit vaginal smooth muscle cell cultures: Effects of vasoactive agents on intracellular levels of cyclic nucleotides.  Mol. Cell Biol. Res. Commun. 2: 131 - 137, 1999.
  • 124. Berman, J.R., Berman, L.A., Werbin, T.J., Flaherty, E.E., Leahy, N.M. and Goldstein, I.: Clinical evaluation of female sexual function: Effects of age and estrogen status on subjective physiologic responses.  Int. J. Impot. Res. 11 (Suppl 1): S32 - 38, 1999.
  • 125. Ricchuti, V.S., Haas, C.A., Seftel, A.D., Chelimsky, T. and Goldstein, I.: Pudendal nerve injury associated with avid bicycling.  J. Urol. 162: 2099 - 2100, 1999.
  • 126. Traish, A.M., Kim, N.N., Goldstein, I. And Moreland, R.B.: Alpha-adrenergic receptors in the penis: Identification, characterization and physiological function.  J. Androl. 20: 671 - 682, 1999.
  • 127. Udelson, D., Park, K., Sadeghi-Najed, H., Salimpour, P., Krane, R.J. and Goldstein, I.: Axial penile buckling forces vs. Rigiscan radial rigidity as a function of intracavernosal pressure: Why Rigiscan does not predict functional erections in individual patients.  Int. J. Impot. Res. 11: 327 - 337, 1999.
  • 128. Goldstein, I.: A 36 week, open label, non-comparative study to assess the long-term safety of sildenafil citrate (Viagra) in patients with erectile dysfunction. Int. J. Clin. Pract. Suppl. 102: 8 - 9, 1999.
  • 129. Berman, J.R., Berman, L.A., Werbin, T.J. and Goldstein, I.: Female sexual dysfunction: Anatomy, physiology, evaluation and treatment options.  Curr. Opin. Urol. 9: 563 - 568, 1999.
  • 130. Montague, D.K., Padma-Nathan, H., Rosen, R., Sadovsky, R., Segraves, R.T. and Shabisgh, R.: The process of care model for evaluation and treatment of erectile dysfunction.  Int. J Impot. Res. 11: 59 - 74, 1999. 
  • 131. Shabsigh, R., Padma-Nathan, H., Gittleman, M., McMurray, J., Kaufman, J. and Goldstein, I.: Intracavernosal alprostadil alfadex is more efficacious, better tolerated and preferred over intraurethral alprostadil plus optional Actis: A comparative, randomized, crossover, multicenter study.  Urology 55: 109 - 113, 2000.
  • 132. Basson, R., Berman, J., Burnett, A., Derogatis, L., Ferguson, D., Fouircroy, J., Goldstein, I., Graziottin, A., Heiman, J., Laan, E., Leiblum, S., Padma-Nathan, H., Rosen, R., Segraves, K., Segraves, R.T., Shagsigh, R., Sipski, M., Wagner, G. and Whipple, B.:  Report of the International Consensus Development Conference on female sexual dysfunction: Definitions and classifications.  J. Urol. 163: 888 - 893, 2000.
  • 133. Shabsigh, R., Padma-Nathan, H., Gittleman, M., McMurray, J., Kaufman, J. and Goldstein, I.: Intracavernosal alprostadil alfadex (EDEX/Viridal) is effective in patients with erectile dysfunction after failing sildenbafil (Viagra)  Urology 55: 477 - 480, 2000.
  • 134. Saenz de Tejada, I., Kim, N.N., Goldstein, I. And Traish, A.M.: Regulation of pre-synaptic alpha-adrenergic activity in the corpus cavernosum.  Int. J. Impot. Res. 12 (Suppl): S20 - 25, 2000.
  • 135. Kim, N.N., Goldstein, I., Moreland, R.B. and Traish, A.M.: Alpha-adrenergic receptor blockade by phentolamine increases the efficacy of vasodilators in penile corpus cavernosum. Int. J. Impot. Res. 12 (Suppl): S26 - 36, 2000.
  • 136. Traish, A., Kim, N.N., Huang, Y. H., Goldstein, and Moreland, R.B.: Cyclic AMP regulates mRNA expression of alpha-1d and alpha-2a adrenergic receptors in cultered human penile corpus cavernosum smooth muscle cells.  Int. J. Impot. Res. 12 (Suppl): S41 - 47, 2000.
  • 137. Traish, A., Kim, N.N., Moreland, R.B. and Goldstein, I.: Role of alpha-adrenergic receptors in erectile function. Int. J. Impot, Res. 12 (Suppl): S48 - 63, 2000. 
  • 138. Goldstein, I: Oral phentolamine: An alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction.  Int. J. Impot. Res. 12 (Suppl): S75 - 80, 2000.
  • 139. Lue, T., Goldstein, I. And Traish, A.: Comparison of oral and intracavernosal vasoactive agents in penile erection.  Int. J. Impot. Res. 12 (Suppl): S81 - 88, 2000.
  • 140. Berman, J.R., Adhikari, S.P. and Goldstein, I.: Anatomy and physiology of female sexual function and dysfunction: Classification, evaluation and treatment options.  Eur. Urol. 38: 20 - 29, 2000.
  • 141. Goldstein, I.: The mutually reinforcing triad of depressive symptoms, cardiovascular disease and erectile dysfunction.  Am. J. Cardiol. 86: 41 - 45, 2000.
  • 142. DeBusk, R., Drory, Y., Goldstein, I., Jackson, G., Kaul, S., Kimmel, S.E., Kostis, J.B., Kloner, R.A., Lakin, M., Meston, C.M., Mittleman, M., Muller, J.E., Padma-Nathan, H., Rosen, R.C., Stein, R.A. and Zusman, R.: Management of sexual dysfunction in patients with cardiovascular disease: Recommendations of the Princeton consensus panel.  Am. J. Cardiol. 86: 62 - 68, 2000.
  • 143. Goldstein, I., Bancroft, J., Guiliano, F., Heaton, J.P.W., Lewis, R.W., Lue, T.F., McKenna, K.E., Padma-Nathan, H., Rosen, R., Sachs, B.D., Segraves, R.T., Steers, W.D.: Male Sexual Circuitry. Sci Am. 283: 70 - 75, 2000.
  • 144. Derby, C.A., Mohr, B.A., Goldstein, I., Feldman, H.A., Johannes, C.B. and McKinlay, J.B.:  Modifiable risk factors and erectile dysfunction: Can lifestyle changes modify risk? Urology. 56: 302-6, 2000.
  • 145. Udelson D and Goldstein I.  Reply to Editorial Comments on 'Axial penile buckling forces vs Rigiscan radial rigidity as a function of intracavernosal pressure: Why Rigiscan does not predict functional erections in individual patients'.  Int. J. Impot. Res. 12: 3-8, 2000.
  • 146. Min K, Kim NN, McAuley I, Stankowicz M, Goldstein I and Traish AM.:  Sildenafil augments pelvic nerve-mediated female genital sexual arousal in the anesthetized rabbit.  Int. J. Impot. Res. 12 Suppl 3:S32-9, 2000.
  • 147. Goldstein I.:  Screening for erectile dysfunction: Rationale.  Int. J. Impot. Res. 12 Suppl 4: S147-51, 2000.
  • 148. Goldstein I.:  Female sexual arousal disorder: New insights. Int. J. Impot. Res. 12 Suppl 4: S152-7, 2000.  
  • 149. Park, K., Tarcan, T., Goldstein, I., Siroky, M.B., Krane, R.J. and Azadzoi KM.:  Atherosclerosis-induced chronic arterial insufficiency causes clitoral cavernosal fibrosis in the rabbit.  Int. J. Impot. Res. 12: 111-6, 2000.
  • 150. Goldstein I, Auerbach S, Padma-Nathan H, Rajfer J, Fitch W and Schmitt L.:  Axial penile rigidity as primary efficacy outcome during multi-institutional in-office dose titration clinical trials with alprostadil alfadex in patients with erectile dysfunction. Int. J. Impot. Res. 12: 205-11, 2000.
  • 151. Tarcan, T., Siroky, M.B., Park, K., Goldstein, I. and Azadzoi, K.M.:  Systemic administration of apomorphine improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit.  Int. J. Impot. Res. 12:235-40, 2000.
  • 152. Kim NN, Huang Y, Moreland RB, Kwak SS, Goldstein I, Traish A.  Cross-regulation of intracellular cGMP and cAMP in cultured human corpus cavernosum smooth muscle cells.  Mol Cell Biol Res Commun. 4:10-4, 2000.
  • 153. Berman, L.A., Berman, J.R., Chhabra, S. and Goldstein. I.:  Novel approaches to female sexual dysfunction.  Expert Opin Investig Drugs. 10: 85-95, 2001.
  • 154. Goldstein, I., Carson, C., Rosen, R. and Islam, A.:  Vasomax for the treatment of male erectile dysfunction.  World J. Urol. 19(1): 51-6, 2001.
  • 155. Goldstein, I., Payton T.R. and Schechter, P.J.:  A double-blind, placebo-controlled, efficacy and safety study of topical gel formulation of 1% alprostadil (Topiglan) for the in-office treatment of erectile dysfunction. Urology. 57: 301-5, 2001.
  • 156. Goldstein. I.:  Editorial: Erectile function after treatment for prostate cancer.   J. Urol. 165: 440, 2001.
  • 157. Min K, O'Connell L, Munarriz R, Huang YH, Choi S, Kim N, Goldstein I, Traish A.  Experimental models for the investigation of female sexual function and dysfunction.  Int J Impot Res. 2001 Jun;13(3):151-6. Review.
  • 158. Porst H, Rosen R, Padma-Nathan H, Goldstein I, Giuliano F, Ulbrich E, Bandel T. The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial.  Int J Impot Res. 2001 Aug;13(4):192-9. 
  • 159. Kim NN, Huang YH, Goldstein I, Bischoff E, Trais AM.  Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor.  Life Sci. 2001 Sep 28;69(19):2249-56.
  • 160. Marceau L, Kleinman K, Goldstein I, McKinlay J.  Does bicycling contribute to the risk of erectile dysfunction? Results from the Massachusetts Male Aging Study (MMAS).  Int J Impot Res. 2001 Oct;13(5):298-302. 
  • 161. Berman JR, Berman LA, Lin H, Flaherty E, Lahey N, Goldstein I, Cantey-Kiser J.  Effect of sildenafil on subjective and physiologic parameters of the female sexual response in women with sexual arousal disorder.  J Sex Marital Ther. 2001 Oct-Dec;27(5):411-20.
  • 162. Berman LA, Berman JR, Bruck D, Pawar RV, Goldstein I.  Pharmacotherapy or psychotherapy?: effective treatment for FSD related to unresolved childhood sexual abuse.  J Sex Marital Ther. 2001 Oct-Dec;27(5):421-5.
  • 163. Berman LA, Berman JR, Werbin T, Chabra S, Goldstein I.  The use of the Female Intervention Efficacy Index (FIEI) as an immediate outcome measure of medical intervention to treat female sexual dysfunction.  J Sex Marital Ther. 2001 Oct-Dec;27(5):427-33.
  • 164. Billups KL, Berman L, Berman J, Metz ME, Glennon ME, Goldstein I.  A new non-pharmacological vacuum therapy for female sexual dysfunction.  J Sex Marital Ther. 2001 Oct-Dec;27(5):435-41.
  • 165. Min K, Munarriz R, Berman J, Kim NN, Goldstein I, Traish AM, Stankovic MR.  Hemodynamic evaluation of the female sexual arousal response in an animal model. J Sex Marital Ther. 2001 Oct-Dec;27(5):557-65.
  • 166. Sax DS, Berman JR, Goldstein I.  Female neurogenic sexual dysfunction secondary to clitoral neuropathy.  J Sex Marital Ther. 2001 Oct-Dec;27(5):599-602.
  • 167. Berger R, Billups K, Brock G, Broderick GA, Dhabuwala CB, Goldstein I, Hakim LS, Hellstrom W, Honig S, Levine LA, Lue T, Munarriz R, Montague DK, Mulcahy JJ, Nehra A, Rogers ZR, Rosen R, Seftel AD, Shabsigh R, Steers W.  Report of the American Foundation for Urologic Disease (AFUD) Thought Leader Panel for evaluation and treatment of priapism.  Int J Impot Res. 2001 Dec;13 Suppl 5:S39-43.
  • 168. Kim NN, Dhir V, Azadzoi KM, Traish AM, Flaherty E, Goldstein I.  Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction.  J Androl. 2002 Jan-Feb;23(1):76-83.
  • 169. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA.  Oral sildenafil in the treatment of erectile dysfunction. 1998. J Urol. 2002 Feb;167(2 Pt 2):1197-203; discussion 1204. 
  • See additional publications by Dr. Goldstein by clicking on the following link: http://www.SanDiegoSexualMedicine.com and then selecting "Publications".

Professional Highlights

Education and Fellowships

  • Brown University, ScB, 1971
  • McGill University,  M.D.C.M., 1975
  • Internship:   Royal Victoria Hospital, Montreal, 1975-1976
  • Residency in Surgery: University Hospital, Boston, MA 1976-1977
  • Residency in Urology: University Hospital, Boston, MA, 1977-1980
  • Fellowships, Urology
  • University Hospital, Boston, MA, 1980-1981
  • Clinical Investigator Award, NIAMDDK, 1981-1984
  • National Kidney Foundation Fellow 1981-1982

Certifications

American Board of Urology

Areas of Special Interest

Memberships

  • International Society for the Study of Vulvovaginal Disease  
  • American Association of Sex Educators, Counselors and Therapists 
  • International Academy of Sex Researchers    
  • International Society for the Study of Women’s Sexual Health   
  • Sexual Medicine Society of North America    
  • International Society for Sexual Medicine    
  • Western Section, AUA      
  • ΑΩΑ Boston University School of Medicine    
  • American College of Surgeon American Urological Association

Treatment and Services

 

For erectile dysfunction:

  • Microvascular arterial bypass surgery 
  • Implantation penile prosthesis
  • Intracorporal injection therapy
  • autologous stem cell injection

For Peyronie's disease:

  • Xiaflex
  • Intralesional interferon

Therapies for FSD:

  • Vestibulectomy
  • Hormonal therapy
  • Other treatments for low desire, PGAD, Post-finasteride syndrome

Honors

  •  
  • SMSNA Lifetime Achievement Award
  • New Orleans, LA 2013
  •  
  • ISSWSH Award for Distinguished Service in Women’s Sexual Health
  • Jerusalem, Israel 2012
  •  
  • Winner, Healthcare Champions Award
  • San Diego Business Journals, 2011
  •  
  • Finalist, Healthcare Champions Award
  • San Diego Business Journals, 2010
  •  
  • Gold Medal Award 
  • World Association for Sexual Health
  • Goteburg, Sweden 2009
  •  
  • Finalist, Healthcare Champions Award
  • San Diego Business Journals, 2009
  •  
  • Lifetime and Career Achievement Award-nominee
  • McGill University Faculty of Medicine
  • Montreal, Canada 2009

Languages Spoken

  • English
  • Spanish

The Sexual Medicine Society of North America, Inc (SMSNA), and Remedy Health Media, LLC (RHM), acknowledge that the providers listed on this website are members of SMSNA. The inclusion of a provider on these pages is not an endorsement by SMSNA or RHM of the provider or the services he or she offers.