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Methadone Reduces Testosterone in Men, But Not Women

Methadone Reduces Testosterone in Men, But Not WomenCanadian researchers have found that when men take the drug methadone for opioid addiction, their testosterone levels drop. But this does not happen to women.

Opioids are pain relievers, such as hydrocodone (Vicodin), oxycodone (OxyContin and Percocet), morphine, and codeine. Doctors sometimes prescribe methadone to people who become addicted to opioids.

This study involved 231 men and women who were dependent on opioids and taking methadone as treatment. Another 783 people who did not use opioids or methadone served as a control group. The researchers collected data on each participant’s substance use and psychiatric history. They also took blood and urine samples.

The research team found that the men who took methadone had much lower testosterone levels than the men in the control group: an average of 100.10 ng/dL compared to 414.74 ng/dL.


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