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Ospemifene Improves Vaginal and Vulvar Structure in Postmenopausal Women

Researchers worked with 20 postmenopausal women who were scheduled for gynecological procedures. Eleven women had been taking ospemifene for at least a month. The remaining nine women had not taken the drug.

During surgery, vaginal and vulvar biopsies was taken from each woman for further analysis. The researchers compared the tissue structure of the biopsies from each group.

They discovered that the women who took ospemifene had increased epithelial thickness. This means that the area of cells lining the vagina were thicker.

Women in the ospemifene group also had more glycogen (cells that store glucose) and a greater proliferation index (a greater number of cells dividing). The researchers found more collagen, too. Collagen is a type of protein that acts a scaffold, binding cells and tissues together.

What do these technical terms mean for women with vulvar and vaginal atrophy? In short, the women who took ospemifene had improvements in the physiological makeup of their vagina and vulva, which are linked to fewer VVA symptoms and more comfortable sex.

To learn more about ospemifene, menopause, and sex, please see these links:

Ospemifene Leads to Healthier Genitals, Less Pain for Postmenopausal Women

Ospemifene May Ease Menopause Symptoms Beyond Painful Intercourse

Sex for Women After 50

Vulvar and Vaginal Atrophy


Contemporary OB/GYN

Orvos, Judith M., ELS

“Ospemifene’s effect on vaginal tissue”

(December 11, 2018)

“Osphena Approval History”

The Journal of Sexual Medicine

Alvisi, Stefania, MD, et al.

“Structure of Epithelial and Stromal Compartments of Vulvar and Vaginal Tissue From Women With Vulvo-Vaginal Atrophy Taking Ospemifene”

(Full-text. Published online: November 13, 2018)

Medical News Today

“Collagen: What is it and what are its uses?”

(Last updated: June 16, 2017)



(Last revised: February 15, 2017)

National Cancer Institute

“Definition of proliferative index”

Science Daily


“Vulvar and Vaginal Atrophy”

(June 26, 2013)

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