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Conditions: Erectile Dysfunction

Transurethral Agents - Erectile Dysfunction

What are the side effects or potential complications of urethral suppositories?

The most common side effects are pain and minor discomfort in the penis and perineum (area between scrotum and rectum) and dizziness. These side effects are reported in less than 5% and 2% of men, respectively, and often go away during treatment as the body adjusts to the medicine. Because of the potential for dizziness, it is often recommended that the first dose of the agent, particularly 500 or 1000 mgs, be given in the physician's office.

Rare side effects that require a doctor's immediate attention include an erection lasting over four hours (known as priapism) or an erection becoming painful.

When using alprostadil in its suppository form, it is important to use a condom when having sexual intercourse with a pregnant female. Although harm to the fetus is unlikely, using a condom will protect the fetus from exposure to this medicine. If a woman can become pregnant, use of contraceptive methods is recommended because the effects of this medicine on early pregnancy are not known.


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