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Conditions: Low Testosterone

Testosterone Replacement Therapy Rarely Prescribed for Hypogonadal Men

The Controversy

TRT has been the subject of much debate over the last couple of years, with some researchers finding an association between TRT and elevated risk of cardiovascular events.

However, some scientists have questioned the reliability of these studies, especially the methodologies used. Other studies have found that men are not at higher risk of cardiovascular problems and that TRT might actually be protective.

Earlier this year, the FDA called for testosterone manufacturers to include warnings about these possible risks on all product packaging. The agency also reminded the medical community that it has approved TRT only for men with hypogonadism – low testosterone caused by problems in the testes or brain.

In other words, TRT has not been FDA-approved for age-related hypogonadism, the natural decline in testosterone that men experience as they get older. Such hormonal decreases can make men feel sluggish, depressed, and less interested in sex. Some patients find they feel better with TRT.

It’s unclear whether the controversy has steered some clinicians away from prescribing the therapy. Still, if you think testosterone would benefit your patients, it’s important to understand the pros and cons.


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