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Clomiphene Citrate Might Preserve Fertility in Men with Low Testosterone

In contrast, clomiphene citrate works by increasing luteinizing hormone and follicle-stimulating hormone amounts in the testes, stimulating testosterone and sperm production.

The Sexual Medicine Reviews study, published online in December 2018, examined medical literature related to clomiphene citrate, testosterone, and fertility in men.

The researchers found that the clomiphene citrate generally relieved low testosterone symptoms and improved erectile function and bone density. There was less known about effects on fertility rates, although a meta-analysis of the few existing studies revealed “significant improvement.”

There was also little data on the side effects of clomiphene citrate. Headache, dizziness, and gynecomastia (breast enlargement) have been reported.

“Despite these reports, [clomiphene citrate] is generally considered to be safe and well tolerated,” the authors wrote.

They added that clomiphene citrate “should remain in the armament of urologists treating hypogonadal men.” (Note: Hypogonadism is the medical term for low testosterone.)


International Society for Sexual Medicine

“Can testosterone replacement therapy (TRT) make a man infertile?”

“How is low testosterone treated?”

Sexual Medicine Reviews

Wheeler, Karen M., MD, PHD, et al.

“Clomiphene Citrate for the Treatment of Hypogonadism”

(Full-text. Published online: December 3, 2018)

You and Your Hormones (Society for Endocrinology)

“Follicle stimulating hormone”

(Last reviewed: February 2018)

“Luteinising hormone”

(Last reviewed: February 2018)

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