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Fibrosis Could Be Key to Understanding Peyronie’s Disease

Fibrosis Could Be Key to Understanding Peyronie’s DiseasePeyronie’s disease is a complicated condition, especially since scientists still aren’t sure of its exact cause. And while current treatments, like surgery and injection therapy, can be effective, they manage symptoms rather than target causes. 

With this in mind, a team of scientists decided to further investigate potential causes of Peyronie’s disease to see how future treatments might develop. They published their findings in April 2019 in the journal Sexual Medicine Reviews

Men with Peyronie’s disease have a distinct curve in their penis. The curve comes from the formation of hardened, fibrous plaques on the tunica albuginea – the membrane that surrounds two chambers of the penis that fill with blood during an erection (corpora cavernosa). 

In its first stage, Peyronie’s disease can be painful. By its second stage, the condition typically results in “a stable, permanent, more-often-then-not painless deformity.” However, that deformity can make intercourse difficult, and some men develop erectile dysfunction (ED).


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