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In Older Men, Testosterone Therapy Doesn’t Increase Risk of Prostate Cancer

In Older Men, Testosterone Therapy Doesn’t Increase Risk of Prostate CancerMen who undergo testosterone replacement therapy (TRT) to treat age-related low testosterone are not at higher risk for prostate cancer, according to research in the American Journal of Epidemiology.

Typically, TRT guidelines advise against the use of TRT in men who have either had prostate cancer in the past or are at risk for it in the future. The hormone testosterone can fuel the growth of prostate cancer cells.

It was unclear whether taking testosterone increased a man’s risk for prostate cancer, however.

TRT is often prescribed to men with low testosterone. (The medical term for this condition is hypogonadism.) The treatment is approved for men whose bodies cannot produce enough testosterone on their own, usually due to problems with the testes (the glands that make this hormone) or areas of the brain that trigger testosterone production.

However, men’s bodies gradually start producing less testosterone as they get older. Eventually, men might start feeling fatigued, moody, and less interested in sex. Some doctors prescribe TRT “off-label” to treat these symptoms. (Off-label treatments can help certain conditions, but aren’t approved by a regulatory agency for that purpose.)

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