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Scientists Investigate Health Risks of Testosterone Replacement Therapy

Doctors might prescribe TRT in these situations, but the approach has been controversial, especially for aging men. Past studies have suggested risks to heart health; others have found no risks whatsoever. For the most part, these studies focused on older men.

The current study, published in February 2018 in BJU International, looked at the effects of testosterone therapy in a group of younger, healthier men. In particular, the authors considered the risks of blood clots, cardiovascular events (such as stroke or heart attack), and obstructive sleep apnea (OSA).

Working with a database of military servicemen between the ages of 40 and 60 in the United States, the researchers identified 3,422 men who received TRT between 2006 and 2010. For comparison, they identified 3,422 additional men who did not take testosterone, but who matched the original group in age, race, military rank, marital status, health status, and residential region.

When the researchers compared the two groups, they discovered that the men on TRT went longer without any cardiovascular events and had lower risk for coronary artery disease. Risks of stroke, congestive heart failure, and blood clots were similar between the two groups.

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