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Scientists Investigate Health Risks of Testosterone Replacement Therapy

However, men in the TRT group were at higher risk for OSA. The research team determined that the 2-year absolute risk for OSA was 17% for men in the TRT group and 13% for men who were not on TRT. This means that 17 out of every 100 men in the TRT group would develop OSA within 2 years, compared to 13 out of every 100 men in the control group.

While associations between TRT and OSA have been found in smaller studies, this was the first time a large, national study had this result. The researchers didn’t know exactly why, but it’s possible that androgens like testosterone may affect airways and oxygen consumption.

They acknowledged several limitations in the study. For example, they did not know the causes of the men’s low testosterone, nor did they have measurements of the men’s testosterone levels or doses over time. Also, results from this military population might not be applicable to civilian men.

The authors recommended that doctors discuss the possibility of OSA with men who are considering testosterone replacement therapy.


BJU International

Cole, Alexander P., et al.

“Impact of testosterone replacement therapy on thromboembolism, heart disease and obstructive sleep apnoea in men”

(Full-text. First published: February 27, 2018)

Renal and Urology News

Charnow, Jody A.

“Testosterone Replacement Therapy Does Not Raise CV Risks”

(March 5, 2018)

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