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Some Men with Peyronie’s Don’t Respond to CCH Injections

Some Men with Peyronie’s Don’t Respond to CCH InjectionsFor men with Peyronie’s disease, treatment with collagenase clostridium histolyticum (CCH) has become more popular over the years. However, some men respond better to this therapy than others, a situation that prompted a recent Journal of Sexual Medicine study.

One of the most common characteristics of Peyronie’s disease is a distinct curve that develops when the penis is erect. This curve is caused by areas of hardened scar tissue (plaques) that form just beneath the surface of the skin. In some cases, the plaques become calcified, hardening further.

With plaques present, the penis becomes less flexible, forming a curve. For some men, the penis takes on an hourglass shape or a “hinge” effect. Sexual intercourse can become quite difficult, and many men experience pain.

In addition to CCH injection therapy, Peyronie’s disease can be treated in several ways, including medications, traction (a device that straightens the penis), and surgery.

In this study, the researchers looked into some of the reasons men might not have success with CCH.

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