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Conditions: HSDD

Addyi: Information for Healthcare Providers

How does Addyi work?

Some call Addyi the “female Viagra,” but it that’s not quite accurate. Viagra, prescribed for erectile dysfunction, works on a man’s genitals, allowing more blood flow to the penis. Addyi works on neurotransmitters in a woman’s brain.

Addyi targets three neurotransmitters. Two – dopamine and norepinephrine – promote sexual excitement. Addyi raises levels of these chemicals. The third – serotonin – is involved with sexual inhibition. Accordingly, Addyi lowers serotonin levels.

Because Addyi can cause drowsiness, it should be taken at bedtime. The standard dose is 100 mg of flibanserin in pill form.

Is Addyi safe?

Clinical trials have found Addyi to be safe for most women, but not all. Addyi is contraindicated for women with hepatic impairment and those who take CYP3A4 inhibitors. Also, Addyi cannot be mixed alcohol.

Packaging materials for Addyi will include a Boxed Warning from the FDA, indicating increased risk of hypotension (low blood pressure) and syncope (loss of consciousness) for some women.

Full prescribing information may be found here.


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