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About 20% of Men with Peyronie’s Disease Stop Injection Therapy Early

Jun 26, 2019

About 20% of Men with Peyronie’s Disease Stop Injection Therapy EarlyApproximately one in five men who start intralesional injection therapy to treat Peyronie’s disease don’t complete the recommended eight-injection protocol, according to new research in Sexual Medicine Reviews.

A review of 15 relevant studies found that discontinuation rates ranged from 13% to 56%, depending on the study design.

Peyronie’s disease is characterized by areas of hardened scar tissue called plaques. Because the plaques make the penis less flexible, a distinct bend develops. For some men, the curve makes intercourse quite difficult. Experts aren’t sure what causes the condition, but some believe it stems from an injury to the penis that doesn’t heal properly.

Treatments for Peyronie’s disease vary depending on the symptoms. Surgery to straighten the penis is one option. But some men undergo a less invasive route – intralesional injections. This therapy involves injecting a substance called Clostridium histolyticum (CCh) directly into the plaques.

Injections can be effective, but the process takes time. Therapy usually includes eight injections given periodically over several months at a doctor’s office. Men may experience pain, itching, swelling, bruising, or bleeding. They might need to abstain from sex. The cost of treatment, if not covered by medical insurance, can be burdensome, too.

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