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Clomiphene Citrate Might Preserve Fertility in Men with Low Testosterone

Feb 12, 2019

Clomiphene Citrate Might Preserve Fertility in Men with Low TestosteroneMen with low testosterone might consider taking clomiphene citrate instead of undergoing testosterone replacement therapy, especially if they wish to father children later on, according to new research.

Clomiphene citrate therapy has been an off-label treatment for low testosterone, since the 1970s, the authors said.

Men’s testosterone levels gradually decline as they get older. This hormonal drop can leave men feeling tired and depressed. Their sex drive and erections might suffer, and their muscles could weaken.

Testosterone replacement therapy can boost a man’s levels and relieve his symptoms. It is usually administered through gels, patches, injections, or implanted pellets.

However, one problem with replacement therapy is its potential effects on fertility.

Typically, when a man’s body needs to make testosterone, the pituitary gland “notices” the deficit and releases two hormones – luteinizing hormone (LH) and follicle-stimulating hormone (FSH) – to start testosterone production in the testes. These hormones also help with the development of sperm.

When a man has synthetic testosterone in his system, his pituitary gland doesn’t register any deficit, so LH and FSH aren’t sent to the testes and less sperm is produced.

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