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Jun 18, 2013

Lybrido and Lybridos: Similarities and Differences

Lybrido and Lybridos vary slightly. Both contain testosterone, a hormone associated with sex drive.

Lybrido contains an ingredient similar to Viagra, an erectile dysfunction medication for men. This ingredient can improve blood flow to the genitals and help a woman with physical sexual response.

On its website, Emotional Brain explains it this way: “Lybrido was the first product we developed for the treatment of HSDD. It proved effective for women with low sex drive and motivation as a result of insensitivity to sexual cues.”

Lybridos – with the S at the end – does not contain the Viagra-like ingredient. Instead, it contains buspirone, an anti-anxiety medication. According to Emotional Brain, this version of the drug “is designed specifically for the treatment of women who suffer from HSDD as a result of inhibitory mechanisms in the brain resulting from negative associations with sex.”

Both drugs would be taken “on demand.” This means a woman would take either Lybrido or Lybridos about three hours before she planned to have sex.

The drugs have been called the “female Viagra.” But this comparison isn’t quite accurate. Viagra helps men with erections by increasing blood flow to the penis. This blood is essential for an erection rigid enough for sex.

Lybrido and Lybridos are a little different, as they act more on the brain. Some believe a woman’s brain her most important sexual organ. Dopamine, a chemical produced in the brain, plays a role in sexual desire. But sometimes dopamine can be out of balance. Lybrido can help with this.

In the case of Lybridos, the buspirone is included to curb inhibitory responses triggered by the brain.


Kirkey, Sharon

“Race to market the first pill to enhance a woman’s libido”

(June 2, 2013)

The Daily Telegraph via Business Insider

Bryant, Ben

“A 'Women's Viagra' May Finally Be Available By 2016”

(May 27, 2013)

Emotional Brain

“Different Causal Mechanisms for HSDD: Different Treatments”



The Journal of Sexual Medicine

Bloemers, Jos, MSc, et al.

“Toward Personalized Sexual Medicine (Part 1): Integrating the “Dual Control Model” into Differential Drug Treatments for Hypoactive Sexual Desire Disorder and Female Sexual Arousal Disorder”

(Full-text. First published online: November 6, 2012)

The New York Times Magazine

Bergner, Daniel

“Unexcited? There May Be a Pill for That”

(May 22, 2013)

Sexual Medicine Society of North America

“Female Sexual Health”

Schultz, Colin

“Don’t Call Female Desire Drugs ‘Lady Viagra’”

(May 22, 2013)

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